Lesson 8.6.2
8.6.2 Drugs acting on synaptic transmission Quiz: Pearson Edexcel Biology, Unit 8
20 questions
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Lesson 8.6.2, Drugs acting on synaptic transmission: 20 multiple choice questions for the Pearson Edexcel Biology (9BI0), Unit 8: Grey Matter, written with Revision Ninja.
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The 20 questions
-
What type of drug binds to a receptor and mimics the natural neurotransmitter?
- Precursor
- Antagonist
- Inhibitor
- Agonist
-
What type of drug binds to a receptor and blocks the natural neurotransmitter?
- Inhibitor
- Antagonist
- Precursor
- Agonist
-
What effect does a reuptake inhibitor have on neurotransmitter concentration in the synapse?
- Has no effect
- Increases concentration
- Prevents secretion
- Decreases concentration
-
What is the main synaptic effect of inhibiting acetylcholinesterase?
- Blocked calcium entry
- Destroyed ACh receptors
- Decreased ACh concentration
- Prolonged ACh stimulation
-
Which drug increases serotonin release and blocks its reuptake at synapses?
- Penicillin
- Morphine
- MDMA
- L-Dopa
-
What substance is L-Dopa converted into within the brain?
- Acetylcholine
- Serotonin
- Dopamine
- Noradrenaline
-
What main effect does an acetylcholine receptor blocker have at neuromuscular junctions?
- Causes muscle spasms
- Triggers muscle contraction
- Increases membrane depolarisation
- Prevents muscle contraction
-
What type of drug binds to postsynaptic receptors and blocks their activation?
- Agonist
- Reuptake inhibitor
- Neurotransmitter
- Antagonist
-
How does increased presynaptic neurotransmitter release affect postsynaptic membrane depolarisation?
- Stops depolarisation
- Decreases depolarisation
- Prevents depolarisation
- Increases depolarisation
-
How does an acetylcholine antagonist affect the stimulation of a postsynaptic neurone?
- Reduces stimulation
- Increases release
- Increases stimulation
- Prevents reuptake
-
Which type of drug increases heart rate by mimicking noradrenaline at synapses?
- Adrenergic agonist
- Cholinergic antagonist
- Cholinergic agonist
- Adrenergic antagonist
-
What happens to dopamine in the synaptic cleft when its reuptake is blocked?
- It reverses nerve direction
- It diffuses into blood
- It accumulates
- It is destroyed instantly
-
Why does an agonist resistant to enzymatic breakdown produce a prolonged effect?
- Blocks receptors permanently
- Inhibits neurotransmitter synthesis
- Destroys presynaptic vesicles
- Remains bound longer
-
Unlike SSRIs, MDMA increases synaptic serotonin levels by promoting which process?
- Receptor destruction
- Neurotransmitter release
- Enzymatic breakdown
- Neurotransmitter reuptake
-
Which dangerous physical condition can result from excessively high serotonin activity?
- Hypothermia
- Hypoglycaemia
- Bradycardia
- Hyperthermia
-
What primary effect do neuromuscular blocking drugs produce on skeletal muscles?
- Muscle spasticity
- Muscle contraction
- Muscle hypertrophy
- Muscle relaxation
-
What is the primary action of a reuptake inhibitor at a synapse?
- Destroys postsynaptic receptors
- Blocks neurotransmitter reabsorption
- Activates postsynaptic receptors
- Prevents neurotransmitter release
-
What happens to postsynaptic action potential frequency when neurotransmitter release increases?
- It remains zero
- It increases
- It decreases
- It stops entirely
-
Why can drugs that block neurotransmitter reuptake still cause harmful side effects?
- Immediate neurone destruction
- Permanent receptor loss
- Foreign chemical toxicity
- Excess neurotransmitter levels
-
If a postsynaptic response increases from 6 mV to 9 mV, what is the percentage increase?
- 50 per cent
- 66 per cent
- 33 per cent
- 30 per cent
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