Lesson 2.4.2

2.4.2 Mutations and cystic fibrosis Quiz: Pearson Edexcel Biology, Unit 2

20 questions

Written by Revision Ninja · Last reviewed 11 October 2026

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Lesson 2.4.2, Mutations and cystic fibrosis: 20 multiple choice questions for the Pearson Edexcel Biology (9BI0), Unit 2: Genes and Health, written with Revision Ninja.

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The 20 questions

  1. What type of membrane protein is the CFTR protein?

    • Chloride ion channel
    • Glucose carrier protein
    • Sodium ion channel
    • Potassium ion pump

  2. Cystic fibrosis is inherited as which type of allele pattern?

    • X-linked dominant
    • Autosomal recessive
    • X-linked recessive
    • Autosomal dominant

  3. Which mutation causes the deltaF508 allele in cystic fibrosis?

    • Two-base insertion
    • Three-base deletion
    • Single-base substitution
    • Chromosomal inversion

  4. Which mutation type causes a frame shift in a gene?

    • Three-base deletion
    • Inversion mutation
    • Base substitution
    • Single-base insertion

  5. What effect does a silent mutation have on the primary structure of a protein?

    • No change
    • Deletes amino acid
    • Alters folding
    • Adds stop codon

  6. Which of these is an example of an environmental mutagen?

    • Ionising radiation
    • Radio waves
    • Infrared radiation
    • Visible light

  7. Which type of cell must carry a mutation for it to be passed to offspring?

    • Epithelial cell
    • Gamete
    • Somatic cell
    • Stem cell

  8. Which ions are transported out of epithelial cells through active CFTR channels?

    • Calcium ions
    • Potassium ions
    • Chloride ions
    • Sodium ions

  9. Two carriers of the CF allele have a child. What is the probability that the child has cystic fibrosis?

    • 75%
    • 25%
    • 50%
    • 0%

  10. If 1 in 2500 people has cystic fibrosis, what is the approximate frequency of the recessive allele q, under Hardy-Weinberg assumptions?

    • 0.25
    • 0.0004
    • 0.02
    • 0.04

  11. What is deleted from a protein sequence when three consecutive bases are removed from mRNA?

    • Three amino acids
    • One amino acid
    • Two amino acids
    • Entire polypeptide chain

  12. Which property of the genetic code ensures GAA and GAG both code for glutamate?

    • Triplet code
    • Universal code
    • Degenerate code
    • Non-overlapping code

  13. What type of mutation introduces a premature stop codon into a mRNA sequence?

    • Nonsense mutation
    • Silent mutation
    • Frameshift mutation
    • Missense mutation

  14. Why do heterozygous carriers of cystic fibrosis not develop the disease?

    • CF is dominant
    • CFTR is inactive
    • CF is recessive
    • CF is sex-linked

  15. What happens to mucus in lungs when CFTR channels are absent or defective?

    • Dries up completely
    • Stops being produced
    • Becomes very watery
    • Becomes abnormally thick

  16. Can a mutation in a somatic cell be passed on to offspring?

    • Only to sons
    • Only to daughters
    • No
    • Yes

  17. What structure forms when UV light damages adjacent thymine bases in DNA?

    • Thymine monomer
    • Cytosine dimer
    • Guanine dimer
    • Thymine dimer

  18. What type of protein is produced if a frameshift causes a premature stop codon?

    • Full-length functional protein
    • Truncated non-functional protein
    • Elongated functional protein
    • Unaltered protein

  19. What is the main effect of cystic fibrosis on the digestive system?

    • Bile ducts constricted
    • Microvilli destroyed
    • Stomach acid reduced
    • Pancreatic ducts blocked

  20. What is a point mutation?

    • Single base change
    • Whole chromosome addition
    • Chromosome duplication
    • Whole gene deletion

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